Resveratrol – Know your Japanese Knotweed

As a plant-derived substance, resveratrol can be found in various dietary sources including grapes,
berries, peanuts, and red wine. Another important source of resveratrol is the Japanese knotweed,
which has long been used in Japan and China as a traditional herbal remedy and is now available in India
with StemRx Biosciences. The health benefits of Resveratrol are enormous and preclinical studies have
revealed that its superantioxdant and anti-inflammatory properties are helpful in the management of
cancer and cardiovascular disorders. Many in vitro and in vivo clinical studies show that resveratrol is
able to inhibit all carcinogenesis stages (e.g., initiation, promotion and progression) [1, 2]. Along with
anti-inflammatory and antioxidant activity, resveratrol is also shown to improve mitochondrial functions
and biogenesis through SIRT1 (sirtuin 1)/AMPK/PGC1 pathway and vitagenes, which prevent the
deleterious effects triggered by oxidative stress [3]. Resveratrol helps reducing neuronal apoptosis and
thus has several neuroprotective roles in various neurodegenerative impairments, such as Huntington’s,
Parkinson’s, Alzheimer’s as well alcohol-induced neurodegenerative disorders [3, 4]. In a normal
cellular metabolism, there is a constant production of reactive oxygen from the mitochondria.
This is balanced by the production of antioxidant enzymes in the cell, such as superoxide
dismutase (SOD), catalase and glutathione peroxidase. When our body undergoes stress, this
balance is interrupted, and the reactive oxygen species gets active which are responsible for
many skin conditions including skin aging and skin carcinogenesis. Resveratrol helps reducing
oxidative stress and play an important role in maintaining normal cellular function. Known to
rejuvenate skin, resveratrol protects cells against free radicals [5]. Because of the

multimechanistic approach of treating ageing factors related to heart, brain, skin and other
organs of the body Resveratrol is an anti-age wonder drug for you.

  1. Zykova, T.A.; Zhu, F.; Zhai, X.; Ma,W.Y.; Ermakova, S.P.; Lee, K.W.; Bode, A.M.; Dong, Z. Resveratrol
    directly targets COX-2 to inhibit carcinogenesis. Mol. Carcinog. 2008, 47, 797–805.
  2. Pezzuto, J.M. Resveratrol as an inhibitor of carcinogenesis. Pharm. Biol. 2008, 46, 443–573.
  3. Sun, A.Y.;Wang, Q.; Simonyi, A.; Sun, G.Y. Resveratrol as a therapeutic agent for neurodegenerative
    diseases. Mol. Neurobiol. 2010, 41, 375–383.
  4. Bastianetto, S.; Ménard, C.; Quirion, R. Neuroprotective action of resveratrol. Biochim. Biophys. Acta 2015,
    1852, 1195–1201.
  5. Wu, Y.; Jia, L.L.; Zheng, Y.N.; Xu, X.G.; Luo, Y.J.; Wang, B.; Chen, J.Z.; Gao, X.H.; Chen, H.D.; Matsui, M.;
    et al. Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation. J. Eur. Acad.
    Dermatol. Venereol. 2013, 27, 345–350.

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