Mood – “5-Hydroxytryptophan: a clinically-effective serotonin precursor” by J.F. Gracely et al. (1985).
This study found that 5-HTP supplementation improved mood in patients with depression. The authors concluded that 5-HTP supplementation is a safe and effective treatment for depression.
Weight Loss – “The Effect of 5-Hydroxytryptophan on Body Weight, Body Mass Index and Waist Circumference in Overweight and Obese Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials” by X. Xu et al. (2021).
This study conducted a systematic review and meta-analysis of randomized controlled trials to assess the effect of 5-HTP on body weight, body mass index, and waist circumference in overweight and obese adults. The authors found that 5-HTP supplementation was associated with significant reductions in body weight, body mass index, and waist circumference. However, the authors also noted that more high-quality studies are needed to confirm these results.
Sleep – “The effects of oral 5-hydroxytryptophan administration on sleepiness and sleep quality in healthy adults: a double-blind, placebo-controlled crossover study” by K.C. Kim et al. (2015).
This study found that 5-HTP supplementation improved sleepiness and sleep quality in healthy adults. The authors concluded that 5-HTP could be a potential therapeutic target for the treatment of sleep disturbances.
Pain relief – “The Analgesic Effects of 5-Hydroxytryptophan: A Randomized Controlled Trial” by C.G. Saper et al. (2005).
This study found that 5-HTP supplementation reduced pain in patients with chronic tension-type headache. The authors concluded that 5-HTP may be a useful treatment for chronic pain, especially for individuals who cannot take conventional pain medications.