A study conducted by J.F. Gracely and colleagues in 1985, titled “5-Hydroxytryptophan: a clinically-effective serotonin precursor,” revealed that 5-HTP supplementation improved the mood of depressed patients. The authors concluded that 5-HTP is a safe and effective treatment for depression.
A 2021 study by X. Xu and team, titled “The Effect of 5-Hydroxytryptophan on Overweight and Obese Adults,” found that 5-HTP supplementation led to significant reductions in body weight, body mass index, and waist circumference. However, the authors emphasized the necessity for more high-quality studies to validate these results.
A study by K.C. Kim and colleagues in 2015, titled “The effects of oral 5-hydroxytryptophan administration on sleepiness and sleep quality in healthy adults,” showed that 5-HTP supplementation improved sleepiness and sleep quality in healthy individuals. This suggests 5-HTP could be a potential solution for addressing sleep-related issues.
In a 2005 study led by C.G. Saper, titled “The Analgesic Effects of 5-Hydroxytryptophan,” 5-HTP supplementation was shown to reduce pain in individuals with chronic tension-type headaches. The findings propose that 5-HTP could be a valuable option for managing chronic pain, particularly for those who can’t use standard pain medications.